【 Seminar Announcement 】
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Date/Time: October 31, 2013（Thu) Time:16:00-17:00
Place: 3F Seminar room, Nanobiology Building
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Title："Adaptation at the output of the chemotaxis signalling pathway"
Prof. Howard C. Berg
(Department of Molecular & Cellular Biology and of Physics, Harvard University)
----- Abstract -----------------------------------------
Much is known about the motile behavior of Salmonella and Escherichia coli. I will mention some history and then describe two recent vignettes, involving adaptation at the output of the sensory-transduction pathway. Receptor methylation is required for adaptation on the second time scale, which enables cells to make temporal comparisons and swim up spatial gradients of attractants.
Without methylation, one still observes partial adaptation, on the minute time scale, as the motor shifts its operating point. The motor also adapts to changes in viscous load. When the load suddenly increases, additional force-generating units are added one by one; thus, the motor is a mechanosensor.
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Host：Keiichi Namba （4625)
Email: keiichi@fbs.osaka-u.ac.jp
All members of FBS are invited to participate in this seminar.
----------------------------------------
Date/Time: October 31, 2013（Thu) Time:16:00-17:00
Place: 3F Seminar room, Nanobiology Building
----------------------------------------
Title："Adaptation at the output of the chemotaxis signalling pathway"
Prof. Howard C. Berg
(Department of Molecular & Cellular Biology and of Physics, Harvard University)
----- Abstract -----------------------------------------
Much is known about the motile behavior of Salmonella and Escherichia coli. I will mention some history and then describe two recent vignettes, involving adaptation at the output of the sensory-transduction pathway. Receptor methylation is required for adaptation on the second time scale, which enables cells to make temporal comparisons and swim up spatial gradients of attractants.
Without methylation, one still observes partial adaptation, on the minute time scale, as the motor shifts its operating point. The motor also adapts to changes in viscous load. When the load suddenly increases, additional force-generating units are added one by one; thus, the motor is a mechanosensor.
--------------------------------------------------------------
Host：Keiichi Namba （4625)
Email: keiichi@fbs.osaka-u.ac.jp
All members of FBS are invited to participate in this seminar.