Speaker : Dr. Miklós Antal
Professor and Chairman
Department of Anatomy, Histology and Embryology
Faculty of Medicine, Medical and Health Science Center
University of Debrecen, Debrecen, Hungary
Title: Molecular organization of the endocannabinoid signaling system in the superficial spinal dorsal horn of rodents
Date : October 7
Time: 15:30-16:30 Place: Seminar Room (3F), Nanobiology building
Host : Prof. Fujio Murakami (murakami@fbs.osaka-u.ac.jp)
Summary
Extensive research in recent years has consolidated our view on endogenous cannabinoids as powerful regulators of synaptic function throughout the CNS. It is well established that endocannabinoids function as retrograde messengers. They are released from neurons in activity dependent manners and modulate synaptic transmission through presynaptic cannabinoid CB1 receptors. Endogenous cannabinoid signaling plays major roles in the modulation of various functions of the CNS including pain processing in the superficial spinal dorsal horn. Dr. Antal will present their findings concerning the molecular organization of the endocannabinoid signaling apparatus in neural circuits underlying pain processing in the superficial spinal dorsal horn. Special attention will be given to the participation of astrocytes in the spinal edocannabinoid signaling mechanisms.
Professor and Chairman
Department of Anatomy, Histology and Embryology
Faculty of Medicine, Medical and Health Science Center
University of Debrecen, Debrecen, Hungary
Title: Molecular organization of the endocannabinoid signaling system in the superficial spinal dorsal horn of rodents
Date : October 7
Time: 15:30-16:30 Place: Seminar Room (3F), Nanobiology building
Host : Prof. Fujio Murakami (murakami@fbs.osaka-u.ac.jp)
Summary
Extensive research in recent years has consolidated our view on endogenous cannabinoids as powerful regulators of synaptic function throughout the CNS. It is well established that endocannabinoids function as retrograde messengers. They are released from neurons in activity dependent manners and modulate synaptic transmission through presynaptic cannabinoid CB1 receptors. Endogenous cannabinoid signaling plays major roles in the modulation of various functions of the CNS including pain processing in the superficial spinal dorsal horn. Dr. Antal will present their findings concerning the molecular organization of the endocannabinoid signaling apparatus in neural circuits underlying pain processing in the superficial spinal dorsal horn. Special attention will be given to the participation of astrocytes in the spinal edocannabinoid signaling mechanisms.